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R-421A Refrigerant 25 lb
R-421A Refrigerant 25 lb
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Refrigerant R-421A is a non-ozone-depleting HFC blend engineered as a direct replacement for R-22 in existing systems. It delivers reliable performance while allowing a smooth transition away from ozone-depleting refrigerants.
One of the key advantages of R-421A is its broad lubricant compatibility. It can be used with mineral oil, alkylbenzene (AB), or polyolester (POE) oils, helping reduce retrofit complexity and minimizing system modifications.
- Residential and commercial air conditioning systems
- Medium-temperature refrigeration
- High-temperature refrigeration applications
- Commercial and industrial cooling systems
When you purchase from Refrigerants Depot, you receive brand new, 100% virgin refrigerants that meet or exceed ARI-700 purity standards. Every cylinder is quality-tested to ensure dependable performance and system safety.
Most orders ship within 1 business day for fast and reliable delivery.

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